BRAF and hemorrhage: Univariate analysis revealed that LDH level (p = 0.006), presence of hemorrhage in the MBMs (p = 0.007), extracranial metastasis (p < 0.001), BRAF mutation status (p < 0.001), number of brain metastases (p < 0.001), maximum diameter of brain metastases (p = 0.038), clinical symptoms (p = 0.001), KPS (p < 0.001), LMR (p = 0.001), brain metastases with a midline shift (p = 0.003), and the presence of liver metastases (p < 0.001) were factors significantly affecting OS (Additional file 2: Figure S1).