NKRF and cancer: Matrine and oxymatrine was the active ingredient of SFAs, which could attenuation of acute lung injury and inhibit the progression of cancer cell lines in vitro [26, 27].Studies confirmed that matrine and oxymatrine inhibited growth of tumour in vivo of mice by regulating GADD45B, Bcl-2, and caspase-3, and also regulated anti-inflammatory responses through AGE expression and Nrf translocation and assist therapy for cardiovascular disease by affecting the JAK2/STAT3 and ATF6 signaling pathway [28-32].