Thus, microvesicles participate in the Tp47-induced recruitment of inflammatory cells in the immunopathogenesis of syphilis, and the Tp47-microvesicle-induced expression of ICAM-1 and VCAM-1 in HUVECs may be a crucial factor in the T. pallidum-induced vascular inflammatory response through the recruitment of monocytes to inflammatory areas. The gene discussed is VCAM1; the disease is syphilis.