BBM increased the intracellular ROS level by downregulating antioxidative genes such as Nrf2, HO-1, SOD2, and GPX-1 to suppress the progression of bladder cancer (28), while a novel synthetic BBM derivative, BBMD3, increased the production of ROS in osteosarcoma cells (29). The gene discussed is HMOX1; the disease is urinary bladder carcinoma.