Our study stratified RA patients by age above or below 60 years and found higher levels of CXCR5 circulating methylation and higher levels of CRP, TJC, VAS Score, DAS28‐ESR, and DAS28‐CRP in RA patients older than 60 years, which typically represent the patient's level of inflammation and disease activity.38, 39. This evidence concerns the gene CRP and rheumatoid arthritis.