In RA patients aged 60 years and above, cg04537602 methylation levels were positively correlated with CRP (r = .31, p = 4.7 × 10−4), tender joint count (TJC) (r = .21, p = .02), visual analog scales score (r = .21, p = .02), DAS28‐CRP (r = .27, p = 2.1 × 10−3), and DAS28‐ESR (r = .22, p = .01). This evidence concerns the gene ESR1 and rheumatoid arthritis.