However, this study has some limitations as follows: (1) the number of our samples is relatively small; (2) the effect of IL‐38 low expression in MIRI mice was not elaborated; (3) the protective role and molecular mechanisms of IL‐38 in ischemic cardiomyopathy have not been thoroughly studied, and we need more in‐depth studies in transgenic mice. The gene discussed is IL1F10; the disease is ischemic cardiomyopathy.