In conclusion, the DpTTDp peptide vaccine was shown to induce a strong IgG response while inhibiting the expression of IL‐4 and IL‐13 cytokines as IgE stimulants, effectively reducing airway inflammation in mice, which are according to the research results of Valenta et al.34This protein represents a promising vaccine for HDM allergy immunotherapy. This evidence concerns the gene IGHE and allergic disease.