The purpose of this study was to investigate the role of YAP in the epithelial barrier of nasal polyps, and to preliminarily study the relationship between YAP and the TGF‐β1 signaling pathway in the epithelial barrier of nasal polyps, so as to provide new ideas for the prevention and treatment of nasal polyps. The gene discussed is TGFB1; the disease is Nasal polyposis.