Higher YES‐associated protein (YAP) level may lead to chronic rhinosinusitis with nasal polyps (CRSwNP) epithelial barrier injury via transforming growth factor‐beta1 (TGF‐β1) signaling pathway and the inhibition of YAP can partially reverse epithelial barrier. Here, TGFB1 is linked to chronic rhinosinusitis with nasal polyps.