In this study, we evaluated the different expression of YAP, TAZ, TGF‐β1, TGF‐β RII, pSmad2/3, Smad2/3, Smad7, ZO‐1, and E‐cadherin in CRSwNP and healthy patients. This evidence concerns the gene SMAD7 and chronic rhinosinusitis with nasal polyps.