Our results are in concordance with the expression of type I IFNs in pancreatic islets of T1D donors.[72, 73, 74] Moreover, more recent studies, such as the Diabetes Virus Detection (DiViD) study, have observed upregulation of several ISGs, including STAT1, IFI6, or MX1 in islets from individuals with T1D.[48, 75]. Here, IFI6 is linked to type 1 diabetes mellitus.