TP53RK and chronic kidney disease: Results showed that the level of TP53RK in the UIR group was significantly higher than that of the control group at days 3 and 21 (Figure S1D, Supporting Information), which represents the AKI–CKD phase and CKD phase, respectively.[13] Protein levels of TP53RK validated using immunohistochemistry and Western blot showed the same trend (Figure 1E–H).