TP53RK was first cloned from an interleukin‐2‐activated cytotoxic T‐cell subtraction library and described as a p53 interacting protein that is able to phosphorylate p53 at Ser15.[6] Being highly expressed in multiple myeloma, colon cancer, and skin cancer, TP53RK is found to promote the proliferation and metastasis of cancer cells. Here, TP53RK is linked to AL amyloidosis.