TP53RK was first cloned from an interleukin‐2‐activated cytotoxic T‐cell subtraction library and described as a p53 interacting protein that is able to phosphorylate p53 at Ser15.[6] Being highly expressed in multiple myeloma, colon cancer, and skin cancer, TP53RK is found to promote the proliferation and metastasis of cancer cells. This evidence concerns the gene TP53RK and skin cancer.