IL10RA and infection: During infection with S. pneumoniae, we used flow cytometry to detect IL-10R on the surface of lung myeloid cell populations and found that IL-10R MFI was significantly reduced in myeloid cell types including neutrophils, AMs, dendritic cells (DCs), and inflammatory monocytes in LysMcrexIL-10Rflox mice compared with WT mice (Supplementary Fig. 1C).