As systemic IL-10 is associated with S. pneumoniae persistence,11 the improved pathogen clearance in LysMcrexIL-10Rflox mice, despite the availability of systemic and pulmonary IL-10, suggests that IL-10R suppresses myeloid cell–mediated protection against S. pneumoniae lung infection. The gene discussed is IL10RA; the disease is susceptibility to pneumonia measurement.