f.[14] As early as 2007, celastrol has been suggested as one of five candidate compounds showing potential as a therapeutic agent.[15] Recently, its leptin‐sensitizing and anti‐obesity effects have attracted worldwide attention.[16, 17, 18] To date, celastrol has been reported to have potential in the treatment of obesity, liver fibrosis, arthritis, and cancer.[18, 19, 20, 21] However, there are no studies available on its antibacterial properties, especially against MRSA, till now. The gene discussed is LEP; the disease is obesity due to melanocortin 4 receptor deficiency.