Orexins are involved in multiple functions often compromised during depressive episodes, such as the regulation of circadian rhythms, cognitive (including attention, learning, and memory) and sexual functioning, positive emotions and social interactions, hedonic capabilities and reward process, visceral functions, sensory systems, and pain (Nollet and Leman, 2013), as well as in anxiety and panic states (Johnson et al., 2012). This evidence concerns the gene HCRT and Anxiety.