NR0B1 and inflammatory bowel disease: 13-Oxo-ODE is a metabolite from de-hydrogenation of 13-hydroxyoctadecadienoic acid (13-HODE), an oxidized product of linoleic acid catalyzed by 12/15-lipoxygenase (LOX) [24, 25], and has been reported as an endogenous ligand for nuclear hormone receptor peroxisome proliferation-activated receptor gamma (PPARγ) involved in inflammatory bowel disease [26, 27].