Our data showed that treatment with A. argyi, a well-known herbal medicine used in the Far East, can be a new strategy to prevent infections with multiple variants of SARS-CoV2 by suppressing their cellular entry as well as viral replication via targeting cellular proteins TMPRSS2 and ACE2 and viral protein RdRp, respectively (Fig. 7 and Additional file 6: Fig. S6D). The gene discussed is ACE2; the disease is infection.