ACTA1 and infection: The decreases in the mRNA expressions of inflammatory genes (Fig. 6E–J and Additional files 3, 4: Figs. S3D–I and S4D–I) and α-SMA expressions (Fig. 6K and Additional files 3, 4: Figs. S3J and S4J) further supported the potential of umbelliferone in preventing infection with SARS-CoV-2 variants in vivo.