Third, we found that an increasing tau burden (as reflected by higher MTL and NEO-T SUVR values on 18F-Florzolotau PET) and a decreasing glucose metabolism (as reflected by lower metaROI SUVR value on 18F-FDG PET) were significantly associated with the severity of cognitive impairment in Aβ+ subjects. Here, MAPT is linked to Cognitive impairment.