For example, Fn stimulates anti-inflammatory myeloid cells in human CRC tissue [55] by activating TIGIT and carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) inhibitory receptors that impair NK and T cell functio [55], creating an immunosuppressive environment conducive to tumor survival and growth [83]. The gene discussed is FN1; the disease is neoplasm.