As myr-AKT/α‐catenin overexpression led to a phenotype with features of well-differentiated HCC (CK19 negative and HNF4α positive tumor cells), it is tempting to speculate that α‐catenin moderately supports liver cancer formation and tumor differentiation via distinct and β-catenin-independent mechanisms. The gene discussed is KRT19; the disease is hepatocellular carcinoma.