ANGPT1 and neoplasm: Notably, intratumoral STING activation also normalizes/reprograms tumor vasculature when administered along with VEGF receptor 2 (VEGFR2) blockers/antagonists by inducing expression of vascular stabilizing genes (e.g., angiopoietin 1 or Angpt1, platelet-derived growth factor receptor-beta or Pdgfr-β, and type IV collagen alpha protein or Col4a) [150].