The decrease in cDC1s in the absence of IRF8 can be attributed to their reprogramming to cDC2-like cells expressing CD11b and signal regulatory protein alpha (SIRPα, recognizes CD47, a “do not eat me signal” expressed on all human tumor cells), which release IL-1β and IL-6 or cDC3 cells in humans [105–107].cDC1s and their progenitors decrease systemically in cancer patients due to a decreased IRF8 expression in cDC progenitors in response to the granulocyte colony-stimulating factor (GCSF) released from local cancer cells. The gene discussed is IL1B; the disease is cancer.