TAMs influence cancer progression through M2 polarization which occurs when TAMs ingest microparticles (MPs) released by tumors in addition to the presence of IL-4, IL-13, prostaglandin E2 (PGE2), M-CSF, vascular endothelial growth factor (VEGF), hypoxia-inducible factor-1 α (HIF-1α), and high lactate levels [53–55]. This evidence concerns the gene VEGFA and cancer.