The proinflammatory cytokine release occurs due to positive regulatory (PR)/SET domain 1 (PRDI-BF1 or PRDM1) or B-lymphocyte-induced maturation protein-1 (BLIMP-1) upregulation in TIME monocytes/macrophages without their death to support tumor growth via promoting M2 polarization. The gene discussed is PRDM1; the disease is neoplasm.