Additionally, Mn2+ coordination micelle (ABZI (STING agonist) + naphthalocyanine (ONc) in maleimide-modified Pluronic F127 (malF127) or ONc-Mn-A-malF127) also forms a novel cancer metalloimmunotherapy to stimulate STING in the TME via capturing in situ tumor antigen (Table 1) [210]. Here, STING1 is linked to cancer.