A higher trend of pro-inflammatory cytokines including IL-1α, IL-1β, IL-6, IL-8, IFN-γ and TNF-α was detected in the plasma from ACLF patients than that from cirrhosis patients, as well as the anti-inflammatory cytokines including IL-4, IL-10 and IL-13. Here, CXCL8 is linked to Cirrhosis.