Several reports also suggest a link between ISG20 and the tumorigenic process of multiple neoplasms, including glioma [14], oral tumor [15], clear cell renal cell carcinoma [16], hepatocellular carcinoma [17], breast cancer [18], and acute myeloid leukemia [19], although the exact ISG20 pathomechanism remains unclear. The gene discussed is ISG20; the disease is breast carcinoma.