Since our in vitro and in vivo results revealed that DPYSL3 increased UC aggressiveness by promoting tumour cell proliferation, migration, and invasion, it is possible that DPYSL3 confers aggressive behaviours on UC cells through profound modulation of the UC cell actin cytoskeleton, boosts epithelial-mesenchymal transition, and promotes cell mitosis. Here, DPYSL3 is linked to neoplasm.