In UTUC, high DPYSL3 expression was associated with advanced-stage (p < 0.001), lymph node metastasis (p < 0.001), high histological grade (p < 0.001), vascular invasion (p < 0.001), perineural invasion (p < 0.001), and a high mitosis rate (p < 0.001). Here, DPYSL3 is linked to metastatic malignant neoplasm in the lymph nodes.