MAPK8 and brain ischemia: The MAPK/JNK/ERK signaling pathway has been implicated in regulation of cell death in differentiated (n = 4) (Cheng et al. 2014; Chi et al. 2019; Xu et al. 2020a; Zeng et al. 2019) and undifferentiated SH-SY5Y (n = 13) cell models of cerebral ischemia (He et al. 2014; Liu et al. 2019a; Marutani et al. 2012; Ruan et al. 2021; Shi et al. 2020; Tian et al. 2020; Wang et al. 2013, 2017, 2019c; Yang et al. 2014).