Epidermal growth factor receptor showed anti-apoptotic effects by activation of the PI3K/AKT pathway in one study with undifferentiated SH-SY5Y and one study with differentiated SH-SY5Y cell models of cerebral ischemia (Lin et al. 2011; Wu et al. 2020b). The gene discussed is AKT1; the disease is Cerebral ischemia.