We employed KC (LSL-KrasG12D/+; Pdx-1-Cre) and KPC (KrasG12D/+; LSL-Trp53R172H/+; Pdx-1-Cre) mice to investigate the epigenetic changes of pancreatic cancer (Fig. 1a). This evidence concerns the gene PDX1 and familial pancreatic carcinoma.