AIFM2 and melanoma: Like the results obtained with Pfa1 and H460 cells, melanoma cell lines dependent on hFSP1Q319K were resistant to icFSP1 in cultured cells and in vivo (Extended Data Fig. 8e–j); in line with this, FSP1 condensates were not observed after icFSP1 treatment in vivo (Fig. 4h and Extended Data Fig. 8h).