AIFM2 and cancer: Thus, it was surprising that treatment of HT-1080 cells, the primary cell model in ferroptosis research, with icFSP1 alone or doxycycline-inducible FSP1 knockout for 72 h was sufficient to trigger ferroptosis (Fig. 1d and Extended Data Fig. 1f–h), in contrast to a panel of different human cancer cell lines (Extended Data Fig. 1c).