Recently, we demonstrated that COVID-19 is associated with a substantial increase in von Willebrand factor (VWF) concentrations, which can exceed the ADAMTS13 processing capacity resulting in the formation of large VWF multimers identical to thrombotic thrombocytopenic purpura (TTP)5,6. This evidence concerns the gene ADAMTS13 and thrombotic thrombocytopenic purpura.