The SNAG domain of Snail is essential for both the suppression of E-cadherin and the activation of ERCC1 in head and neck squamous cell carcinoma cells [24], while in another report, the transactivation of β-catenin-dependent reporter by Snail does not require the SNAG domain but the zinc fingers [41]. The gene discussed is CDH1; the disease is head and neck squamous cell carcinoma.