GPX4 and cancer: Oncology appears to be a particularly interesting field here, as immunogenic cell death—such as pyroptosis—has recently received significant attention in the context of cancer.5 The relevance of RCD in this field is also illustrated, for example, by the fact that the screening of cancer cell lines played a critical role in the identification of glutathione peroxidase 4 as the key regulator of ferroptosis, a mode of RCD characterized by oxidative stress and lipid peroxidation.3 As Zhong et al. report, different cancer cell lines express different isoform compositions of GSDMs.