LEP and obesity due to melanocortin 4 receptor deficiency: Pacific islanders are reported to be genetically predisposed to obesity since they acquired abilities to adapt to their poor environment of food security when originally settled in the Pacific region, thus they may have hereditary traits for elevated risk of obesity (e.g., a genotype of increased leptin levels in Micronesians) [25], and they do not have negative image of obesity in terms of body image perception [26].