On the other hand, it has been reported that loss of Trop-2 promotes carcinogenesis and EMT in squamous cell carcinomas (19) and that a mutation of the Trop-2 gene impairs the function of tight junctions through decreased expression and altered subcellular localization of tight junction proteins claudin-1 and claudin-7 in gelatinous drop-like corneal dystrophy (GDLD) corneas (20, 21). The gene discussed is CLDN7; the disease is gelatinous drop-like corneal dystrophy.