In the current study, we therefore investigated the effects of GIPR/GLP1R agonism on NAFLD development in male APOE∗3-Leiden.CETP (E3L.CETP) mice, a translational humanized mouse model for exploring the effects of pharmacological interventions on insulin resistance, diabetic dyslipidemia and NAFLD.20 This evidence concerns the gene INS and metabolic dysfunction-associated steatotic liver disease.