Whereas many of the gene sets identified by the proteomics analysis as dysregulated in DS were similar to those identified in the transcriptome analysis (e.g., IFN responses, heme metabolism, and estrogen response) (Fig. 1A), others were not (e.g., down-regulation of the coagulation cascade in the proteomics dataset), thus highlighting the value of proteomics analyses as a complement to transcriptome analyses. This evidence concerns the gene IFNA1 and Dravet syndrome.