IFNG and COVID-19: This exercise revealed that, whereas the DS IFN score tracks preferentially with IFNG and IFNL1 in DS, this same ISG signature correlates significantly with eight different IFNs in COVID-19, five of which are type I IFNs (i.e., IFNA2, IFNA7/17/21, IFNA1, IFNA4/16, and IFNA10) (Fig. 2C).