For instance, despite the fact that ANXA1 has been reported as a BLCA prognostic biomarker in BLCA by several studies [38, 39], which was concurrent with our findings (Supplementary Figure 1), we first uncovered that ANXA1 was negatively associated with B cell infiltration levels in BLCA (Figure 4F–4G). This evidence concerns the gene ANXA1 and bladder transitional cell carcinoma.