Expression analysis revealed that 11 genes (MYC, CASP3, CBL, RB1, MAD2L1, PLCG1, CHEK1, FBXW7, NUP155, RAN and DDX55) and 7 genes (RHOA, FMR1, SUPT16H, CALM1, CTCF and UBXN7) were significantly upregulated and downregulated in ccRCC when compared with normal controls, respectively. The gene discussed is CASP3; the disease is nonpapillary renal cell carcinoma.