Neurofibromatoses (NF; NF1, NF2, and schwannomatosis) are nervous system disorders unified by risk of nerve sheath tumors1 that cause significant morbidity, including disfiguring cutaneous tumors (NF1)1,2; complete hearing loss, facial weakness, and poor balance (NF2)3; and chronic pain (schwannomatosis).4 A change in disease nomenclature is underway that considers NF2 a subtype of schwannomatosis (NF2-related schwannomatosis) based on its genetic properties; we retain the 3 subtypes to stratify randomization in the current trial. This evidence concerns the gene NF1 and schwannomatosis.