For those different tertiles of DII, gender, race, serum creatinine, 25(OH)D, eGFR, low eGFR, systolic blood pressure, diabetes mellitus, and the proportions of different CKD stages were significantly different, but not for age, DBP, BMI, WBC count, HDL, albumin, ALP, serum calcium, serum phosphorus, cholesterol, serum glucose, TCG and vitamin D supplement. The gene discussed is ALB; the disease is diabetes mellitus.