Diet supplementation with chenodeoxycholic acid (CDCA) or the bile acid-binding resin colestimide, which favours bile acids synthesis, in mice showed an anti-obesity efficacy associated with the increase of UCP1 and PGC1α mRNA expression levels in BAT depots [110], reduced food intake and increased lipid oxidation in WAT [121]. The gene discussed is UCP1; the disease is obesity due to melanocortin 4 receptor deficiency.