RUNX1 and leukemia: To further evaluate the therapeutic potential of 5hmdC and 5fdC in hematopoietic malignancies, we examined their effects on the colony-forming ability of bone marrow cells derived from two different mouse leukemia models, harboring the fusion oncoproteins AML1-ETO9a (Wang et al. 2011) or Nup98-HoxD13 (NHD13) (Lin et al. 2005), respectively.