To determine the role of FBXL18 in human HCC, a volcano plot was generated and showed that the mRNA levels of FBXL18, CCNF, FBXO43, and FBXW10 were significantly highly expressed in HCC tissues according to The Cancer Genome Atlas (TCGA) dataset (Fig. 1A). The gene discussed is FBXL18; the disease is hepatocellular carcinoma.