FBXL18 and neoplasm: Mice with high FBXL18 expression (OE-FBXL18 mice; n = 14) developed more liver tumors, larger tumor sizes, and increased liver and body ratios compared with WT mice (n = 16) up until 24 weeks, demonstrating that FBXL18 overexpression drives hepatocarcinogenesis in mice (Fig. 2A-C).