Conversely, neutral conclusions were reached when the relationship between serum PCSK9 concentrations and measures of vascular health, and subclinical atherosclerosis were assessed in a cohort consisting of 1,527 middle-aged men (mean age 49.4 years), who were in good health and free of vascular disease, enrolled in the Firefighters and Their Endothelium (FATE) study (37). The gene discussed is PCSK9; the disease is atherosclerosis.