A genome-wide association study and a following Mendelian Randomization analysis, conducted on a cohort of 3,290 individuals of the LIFE-Heart study receiving coronary angiography for suspected coronary artery disease (CAD), with a mean age of 61.7 years, supported the hypothesis of a causal effect of PCSK9 on coronary artery disease status and severity, carotid plaques, and intima-media thickness (33). This evidence concerns the gene PCSK9 and coronary artery disorder.