The ATHEROREMO-IVUS (The European Collaborative Project on Inflammation and Vascular Wall Remodeling in Atherosclerosis—Intravascular Ultrasound) study, performed on 581 patients (mean age 61.5 years) who underwent coronary angiography for acute coronary syndrome (ACS) or stable angina, showed that PCSK9 levels were linearly associated with higher necrotic core fraction in coronary atheromas (35). The gene discussed is PCSK9; the disease is acute coronary syndrome.