As for the composite outcome, even if NT-proBNP alone was not significant, the parameter obtained by its combination with baseline sST2 (AUC 0.88, p < 0.001) showed good outcome prediction at the multivariate analysis [HR for HF hospitalizations 3.23 (1.89–4.35), p < 0.001, log-likelihood = 58.26; HR for CV mortality 3.33 (1.39–5.88), p = 0.010, log-likelihood = 59.37]. This evidence concerns the gene NPPB and hydrops fetalis.