Although NT-proBNP, sST2, Gal-3, and eGFR, when considered individually, have already been demonstrated to have a prognostic role in HF (15–17), to the best of our knowledge, a combination of these parameters and its variations during the course of the disease were not tested in the candidates to CRT implantation in the long-term follow-up. The gene discussed is NPPB; the disease is hydrops fetalis.