CHST3 and neurodegenerative disease: To identify genetic modifiers of HSD-induced impairment of heat avoidance, we performed candidate screening for 13 genes (18 lines), which were selected on the basis of their functions in glucose metabolism (insulin-like signaling, glycolysis, polyol pathway, and hexosamine pathway), stress and cell death signaling, association with human DPN, and neurodegenerative diseases (Table S2).