Among the more consistent results, Notch receptors (NOTCH2 and NOTCH3) negatively correlated with NE scores, whereas Notch inhibitors (DLL3, DTX1, and DTX3) positively correlate with NE scores, consistent with previous findings that Notch activation mediates NE to non-NE transdifferentiation in SCLC.25 The gene discussed is DLL3; the disease is small cell lung carcinoma.