Among the more consistent results, Notch receptors (NOTCH2 and NOTCH3) negatively correlated with NE scores, whereas Notch inhibitors (DLL3, DTX1, and DTX3) positively correlate with NE scores, consistent with previous findings that Notch activation mediates NE to non-NE transdifferentiation in SCLC.25 This evidence concerns the gene DTX1 and small cell lung carcinoma.