They found that low-dose prednisone chronotherapy for RA added to existing DMARD treatment helped significantly reduce morning stiffness, severity of symptoms, and fatigue [30]. RA patients identified with altered clock gene expression may benefit from corresponding treatment with chronotherapy to better manage symptoms and dysregulated sleep. Future research can be focused on expanding clock gene analysis in a larger subset of patients with a focus on BMAL1 and PER genes. Here, CLOCK is linked to rheumatoid arthritis.