It has been shown that abnormal expression of NF-κB is associated with the development of various diseases, such as diabetes, cardiovascular diseases, and cancer, etc. The interconnection between NF-κB and NO is also close, and excessive expression of NF-κB will directly contribute to the abnormal secretion function of NO (Janssen-Heininger et al., 2000), leading to changes in vasodilatory capacity and causing certain risks to human health. The gene discussed is NFKB1; the disease is diabetes mellitus.