PKDCC and cranioectodermal dysplasia: The HH pathway mediators GLI family zinc finger 1 (Gli1) that promotes osteoblast differentiation (48), Intraflagellar transport 122 (Ift122) that was linked to cranioectodermal dysplasia in humans and protein kinase domain containing cytoplasmic (Pkdcc), which regulates craniofacial and long bone development (46) demonstrated higher expression levels in the calvaria compared to cortices.