Finally, additional genes associated with craniosynostosis were strongly expressed in the calvaria compared to the cortical bone, such as Axin2 (6), B cell leukemia/lymphoma 11B (Bcl11b) (49), Interleukin 11 receptor alpha chain 1 (Il11ra1) and Ski sarcoma viral oncogene homolog (Ski) (4), as well as the ephrin receptors Epha4 and Ephb3. The gene discussed is SKI; the disease is craniosynostosis.