(17) on mature animals impedes the comparison of craniosynostosis relevant DEGs that were detected in their studies and the DEGs reported here, such as Axin2, Aristaless-like homeobox 4 (Alx4), Zic family member 1 (Zic1), the Glycoprotein glypican 3 (Gpc3) and ephrin receptors. The gene discussed is ZIC1; the disease is craniosynostosis.