Previous reports suggest that among CU, those who are amyloid-positive show steeper reduction in cortical NDI associated with increasing phosphorylated tau; in turn, those who are tau-positive, show steeper NDI reduction with lower Aβ42/Aβ40.74 It is noteworthy that this pattern of NDI reduction with greater tau and amyloid pathology was observed, despite the lack of amyloid- or tau-positivity, among those with asthma in our study. The gene discussed is MAPT; the disease is asthma.