Further, in contrast to the counterintuitive effects seen with IL-6 and S100B, it is noteworthy that we also found some evidence that asthma moderated associations that appear to be deleterious between glial activity (indicated by YKL-40 and sTREM2) and both white and gray matter microstructure (see Supplementary material (section 4)). The gene discussed is CHI3L1; the disease is asthma.