TGFB1 and neoplasm: Tregs, Forkhead box P3 (FOXP3) expressing CD4+ T cells, are recruited into the TIME through up-regulation of CCR4, CCR5, CCR8, and CCR10 mediated chemotaxis in inflamed tumors by both tumor and immune cells; and CCR4 mediated chemotaxis due to increased CCL22 expression in EGFR mutant non-inflamed tumors, exert their inhibitory effects on CTLs through IL-2 depletion, binding and capturing of co-stimulatory signals on dendritic cells, and the production of immunosuppressive factors, such as TGFβ, IL-10, FGL2, VEGF, and granzymes (101, 102).