OAS1 and infection: Interestingly, whereas TLR4 inhibition (TAK-242, 10 μM) did not alter enhanced OAS1 and IRF7 expression in response to hypoxic priming and SARS-CoV-2 infection, it completely abolished the expression of chemokine ISGs CCL2 and CXCL10 (Figure 7B), despite the fact that the infection rate was not affected (Supplementary Figure 9).