Interestingly, whereas TLR4 inhibition (TAK-242, 10 μM) did not alter enhanced OAS1 and IRF7 expression in response to hypoxic priming and SARS-CoV-2 infection, it completely abolished the expression of chemokine ISGs CCL2 and CXCL10 (Figure 7B), despite the fact that the infection rate was not affected (Supplementary Figure 9). Here, IRF7 is linked to infection.