TRAT1 and type 1 diabetes mellitus: Although no relevant study shows the correlation between TRIM26 and RA, MS, IBD, T1D, we found that TRIM26 is a member of the TRIM protein family, encoded in the locus of major histocompatibility complex Class I region, and TRIM26 interacts with TAB1 and specifically catalyzes K11-linked polyubiquitination of TAB1, which facilitates TAK1 activation and initiates downstream signaling, and finally positively regulated TLRS-mediated inflammatory cytokines (70).