Several significant pathways processes enriched in the tumor-infiltrating CD8+ TRM include positive regulation of cytosolic calcium ion concentration (GO:0007204), multivesicular body sorting pathway (GO:0071985), cell adhesion molecules (CAM; hsa04514), intracellular signal transduction (GO:0035556), defense response to virus (GO:0051607) and response to virus (GO:0009615) (Figure 4B, Table S6). Here, CD8A is linked to neoplasm.